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Technology Overview

OHSU # 3088 — Framework for 3D retinal pathology detection by OCT/OCT-angiography

The current technology provides a platform for a fully-automated OCT-based 3D detection of retinal pathologies with significantly reduced processing requirements, which could allow for more wide-spread adoption of OCT/OCT-angiography 3D analysis.

Technology Overview
Optical coherence tomography (OCT) and its angiography can be used to provide more accurate analysis of retinal pathologies in 3D; however, it can be prohibitively time-consuming and remains under-utilized. The current technology is a framework for structural and angiographic OCT 3D image analysis developed by leaders in the field, which could be incorporated into commercial OCT systems to increase utility of OCT imaging modalities for research and clinical care.
Features of this platform include:

  • Volume-based approach to more accurately detect retinal pathologies in 3D, requiring minimal retinal layer segmentation thereby reducing processing time.
  • Choroidal neovascularization detection without the need for projection artifact removal.
  • Ability to detect the full spectrum of retinal pathologies, including hypo- and hyper-reflectance, neovascularization and nonperfusion.
  • Fully-automated, with incorporation of a pathology index and a reference volumetric retina for faster screening.

Pi et al., “Volume-based, layer-independent, disease-agnostic detection of abnormal retinal reflectivity, nonperfusion, and neovascularization using structural and angiographic OCT.” Biomedical Optics Express 9(2022): 4889-4906. Link

Licensing Opportunity
This technology is available for licensing.