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Technology Overview
OHSU # 2219 — Recombinant human CD74 for cancer and immunology research
Summary
A recombinant chimeric version of CD74 containing the human extracellular domain, which binds MIF-1 and MIF-2 and has the potential as a valuable research tool for cancer and immunology studies examining the CD74-MIF axis.
Technology Overview
CD74 interactions with migration inhibitory factor (MIF) is a growing area of cancer and immunology research. However, current recombinant versions of CD74 have a limited ability to bind MIF. Researchers at OHSU have developed an E. coli-expressed recombinant version of human CD74 with the following properties:
- Improved binding of MIF-1 and MIF-2, as compared to commercially available versions of recombinant CD74.
- Demonstrated ability to bind several antibodies currently used in human CD74 biology research and recombinant human and mouse Class II proteins.
- Stable, with no decrease in activity, when stored at -80 °C in glycerol for up to 6 months.
Publications
Meza-Romero et al., “Increased CD74 binding and EAE treatment efficacy of a modified DRα1 molecular construct.” Metabolic Brain Disease 2019. Link
Benedek et al., “MIF and D-DT are potential disease severity modifiers in male MS subjects.” PNAS 2017. Link
Licensing Opportunity
This technology is available for licensing.
Inventors:
Patents
| Issued | United States | 10,689,446 |
Related Technologies
- OHSU # 2187 — Mouse CD74: Design, codon optimization, cloning, expression in E coli, and purification
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