OHSU # 2850 — Bioactive polymers with anti-fouling properties for medical implants
The development of bacterial biofilms can affect the structural integrity of in-dwelling medical devices and materials, reducing their longevity. Oregon Health & Science University researchers have developed bioactive polymers, which are compatible with traditional dental reconstruction materials and reduce biofilm formation to potentially increase the durability of medical implants, including dental restorations.
Indwelling medical devices and materials are highly susceptible to bacterial colonization, and these bacterial biofilms can be detrimental to the durability of the device. Current methods to control biofilm formation are limited to small molecule rinses, which must be regularly administered, and small molecule sustained release (i.e. leaching), which is eventually depleted. OHSU researcher Dr. Carmem Pfeifer has devised a strategy to incorporate biofilm disrupting (anti-fouling) small-molecule polymers into medically relevant plastics. These materials offer several advantages:
- Demonstrated reduction of S. mutans colonization, an early bacterial colonizer with virulent biofilms that erode dental enamel.
- Lack of broad anti-bacterial properties, allowing for tailored biological activity and prevention of bacterial imbalance.
- Compatibility with dental restoration materials.
- Applicability for wide range of medical devices.
This technology is available for exclusive or non-exclusive licensing.
|Published||United States||US 2021/0284622 A1|