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Technology Overview

OHSU # 2482 — Polymerizable compounds for applications in dental materials

Adhesives are widely used in dentistry to create a bond between teeth and restorative material, but current commercially available dental adhesives are often acidic and undergo degradation in the aqueous oral environment. Oregon Health & Science University researchers have developed an acrylamide based dental adhesive with reduced degradation resulting in a more stable and long-lasting seal of the tooth-filing interface.

Technology Overview
Current dental adhesives often contain methacrylates and high concentrations of hydrophilic and/or ionic monomers, resulting in high levels of water sorption and a progressively degrading bond strength over time due to the action of water and enzymes in the mouth.  Dr. Carmem Pfeifer and colleagues have developed a novel multi-acrylamide based adhesive system with greater hydrolytic and enzymatic stability than currently used adhesives. These methacrylamide-modified adhesives showed microtensile bond strength to human dentin that was comparable to commercially available adhesives 48 hours after application, but greater bond-strength than commercial adhesives at 3 weeks and 6 months after application. The increased bond strength was accompanied by enhanced stability, as demonstrated by higher monomer recovery after water storage and exposure to enzymatic degradation as compared to commercially available adhesives. The enhanced stability of methacrylamide adhesives could provide for longer-lasting dental adhesives and reduced risk of premature un-bonding and dental injuries.

Fugolin et al., “Synthesis of di- and triacrylamides with tertiary amine cores and their evaluation as monomers in dental adhesive interfaces”. Acta Biomaterialia 115(2020):148-159. Link

Licensing Opportunity
This technology is available for licensing.



Issued United States 10,689,329