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OHSU # 2274 — ImmortaMAITs: immortalized Mucosal Associated Invariant T (MAIT) cells as new human cell line reagents for human immunobiology research

Technology Overview

The Immorta-MAITs are human mucosal-associated invariant T (MAIT) cells.  There are ten cell lines which are confirmed to express the MAIT T cell receptor alpha (TRAV1-2) and full TCR sequencing has been performed.  The cell lines stain with an MR1-tetramer loaded with a MAIT antigen 5-OP-RU and not control MR1-tetramer loaded with 6FP.  The Immorta-MAITs are able to grow in a simple media without the addition of cytokines, human serum, or stimulation.  These cell lines are clonal and were generated by single cloning methods from healthy thymus tissue not tumor tissue.  The ten cell lines are Immorta-MAIT EM-D6, EM-D5, EM-C5, EM-B11, IK-C1, IK-B12, JK-A8, MG-B4, MG-A11, and MG-A4.

Licensing Opportunity

These cell lines are available for licensing.

Inventors:

• Marielle Slater (Gold)
• Erin Meermeier (Riscoe)
• Irina Kurtz
• David Lewinsohn

Categories:

• Biological Materials - Cell Lines

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