IRB #

IRB00008466

Title

Relationship between HLA B27, disease status and the human microbiome

Principal Investigator

James Rosenbaum

Study Purpose

The purpose of this study is to learn more about the relationship between the microbes which naturally reside in the gut and other organs of the body and diseases that are associated with a gene called HLA B27. We are also investigating whether the preparation done before colonoscopy procedures changes the bacteria that live in the gut, and how these bacteria vary in different parts of the large intestine.

Medical Condition(s)

Ankylosing Spondylitis (AS)
Inflammatory Bowel Disease
Rheumatoid Arthritis
HLA-B27
Microbiota
Microbiome
Gut
Healthy Volunteers

Eligibility Criteria

-At least 18 years of age
-Scheduled for a routine colonoscopy
-Willing and able to give consent, provide samples and complete study paperwork
-Not pregnant
-No history of bowel or intestine surgery
-No diagnosis or history of colon cancer
-Have not taken any antibiotics in the past 3 months

Healthy Volunteers Needed

Yes

Placebo Chance

Duration of Participation

Your primary involvement will last only on the day of your colonoscopy. All subjects will be asked to obtain a stool sample at home prior to your colonoscopy prep. Subjects who agree to an optional second stool sample will do so within 2-3 weeks after the day of your colonoscopy.

Minors Included

No

Contact

Study Coordinators:

Claire Mitchell
503-494-5070
mitchecl@ohsu.edu

Kimberly Ogle
503-494-5711
b27microbiome@ohsu.edu

Lindsey Watson
503-494-5070
watsolin@ohsu.edu

Puthyda Keath
503-494-5070
keath@ohsu.edu

Sponsor

Recruitment End

01/01/2027

Compensation Provided

Yes

Compensation

$10 clincard upon completion of study specimen(s). For most subjects this will be a one time event. Some subjects will have the opportunity to provide specimen(s) more than once.


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