IRB #
IRB00008466
Title
Relationship between HLA B27, disease status and the human microbiome
Principal Investigator
James Rosenbaum
Study Purpose
The purpose of this study is to learn more about the relationship between the microbes which naturally reside in the gut and other organs of the body and diseases that are associated with a gene called HLA B27. We are also investigating whether the preparation done before colonoscopy procedures changes the bacteria that live in the gut, and how these bacteria vary in different parts of the large intestine.
Medical Condition(s)
Ankylosing Spondylitis (AS)
Inflammatory Bowel Disease
Rheumatoid Arthritis
HLA-B27
Microbiota
Microbiome
Gut
Healthy Volunteers
Eligibility Criteria
-At least 18 years of age
-Scheduled for a routine colonoscopy
-Willing and able to give consent, provide samples and complete study paperwork
-Not pregnant
-No history of bowel or intestine surgery
-No diagnosis or history of colon cancer
-Have not taken any antibiotics in the past 3 months
Healthy Volunteers Needed
Yes
Placebo Chance
Duration of Participation
Your primary involvement will last only on the day of your colonoscopy. All subjects will be asked to obtain a stool sample at home prior to your colonoscopy prep. Subjects who agree to an optional second stool sample will do so within 2-3 weeks after the day of your colonoscopy.
Minors Included
No
Contact
Study Coordinators:
Claire Mitchell
503-494-5070
mitchecl@ohsu.edu
Kimberly Ogle
503-494-5711
b27microbiome@ohsu.edu
Lindsey Watson
503-494-5070
watsolin@ohsu.edu
Puthyda Keath
503-494-5070
keath@ohsu.edu
Sponsor
Recruitment End
01/01/2027
Compensation Provided
Yes
Compensation
$10 clincard upon completion of study specimen(s). For most subjects this will be a one time event. Some subjects will have the opportunity to provide specimen(s) more than once.
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