A Randomized, Phase II Trial of Circulating Tumor DNA-guided Second Line Adjuvant Therapy for High Residual Risk, Stage II-III, Estrogen Receptor Positive, HER2-negative Breast Cancer (DARE)

Principal Investigator

Alexandra Zimmer

Study Purpose

The purpose of this research is to find out if detecting cancer-related abnormal DNA molecules in your blood, called circulating tumor DNA, or ctDNA, can predict a subsequent clinical recurrence of the cancer, and if starting a new treatment when we first detect ctDNA in your blood could prevent, or delay, the clinical recurrence of the cancer.

Medical Condition(s)

High Residual Risk, Stage II-III, Hormone Receptor Positive, HER2 Negative Breast Cancer

Eligibility Criteria

Have Stage II or II, HER2-negavie, ER-positive invasive breast cancer

Currently receiving endocrine therapy and have completed at least 6 months, but no more than 7 years

Clinical and pathological high risk for recurrence

Age Range

18 - 101

Healthy Volunteers Needed


Duration of Participation

Your participation in this study could last up to 7 years.

Minors Included



Knight Cancer Institute Clinical Trials
503 494-1080


CRITERIUM Inc. doing business as Academic Breast Cancer Consortium (ABRCC) with support from Pfizer Pharmaceuticals

Recruitment End


Compensation Provided


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