A Phase 3, Randomized Study of Zanubrutinib (BGB 3111) Compared with Ibrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
The purpose of the study is to compare 2 drugs, an investigational drug called zanubrutinib and an FDA approved drug called ibrutinib, in treating CLL/SLL. The two main objectives of the study are to find out how effectively the study drug controls CLL/SLL, and to compare the side effects of each drug. You will be randomly assigned by a computer to receive either the study drug or ibrutinib. Neither you nor the investigator can choose whether you get the study drug or ibrutinib. You will have an equal chance of being in either group.
Relapsed and/or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
- You must be at least 18 years of age and diagnosed with relapsed/refractory CLL/SLL
- You must be relapsed or refractory to at least 1 prior systemic therapy for CLL/SLL
- You must not have had prior treatment with a BTK inhibitor, such as ibrutinib or acalabrutinib
18 - 99
Healthy Volunteers Needed
Duration of Participation
You will receive either the study drug or ibrutinib until your disease gets worse or the side effects become too severe. After you are done taking the drug, you will be followed long-term for up to 7 years.
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