IRB #

STUDY00019316

Title

[MCW IRB-CML MOU] Treatment Free Remission After Combination Therapy with Ruxolitinib Plus Tyrosine Kinase Inhibitors in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients who Relapsed After a Prior Attempt at TKI Discontinuation

Principal Investigator

Michael Heinrich

Study Purpose

The purpose of this study is to compare the good and bad effects of adding ruxolitinib to the standard chemotherapy vs. using the standard chemotherapy alone.

This study is also looking at the toxicities, progression free survival and overall survival rates in this patient population.

Medical Condition(s)

Chronic Myeloid Leukemia (CP-CML)

Eligibility Criteria

1. Age ≥18
2. Willing and able to give informed consent
3. Diagnosed with CML in chronic phase
4. Previous treatment with at least one tyrosine kinase inhibitor (TKI) such as imatinib, nilotinib, dasatinib, radotinib or ponatinib

Other eligibility will apply.

Age Range

18 - 100

Healthy Volunteers Needed

No

Duration of Participation

Total duration of the trial will be approximately four years (one year on combination treatment phase + three years in the TFR phase).


Minors Included

No

Contact

Clinical Trials Information Line
Phone: 503-494-1080
Email: trials@ohsu.edu

Sponsor

This study is funded by the Incyte Corporation and lead by Sponsor-Investigator, Kendra Sweet at the H. Lee Moffitt Cancer Center.

Recruitment End

08/31/2022

Compensation Provided

No


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