IRB #

STUDY00018504

Title

A Phase II, Open Label, Study of Olaparib and Durvalumab in Patients with Metastatic Triple Negative Breast Cancer

Principal Investigator

Zahi Mitri

Study Purpose

The purpose of this study is to see if we can lower the chance of breast cancer growing, or spreading, by treating participants with a combination of a PARP inhibitor (Olaparib) and an immune therapy (Durvalumab). We also want to learn more about how participants tumors respond to this treatment by performing clinical tests on biopsied tumor tissue.

Medical Condition(s)

Metastatic Triple Negative Breast Cancer

Eligibility Criteria

18 Years and older females
Biopsy proven metastatic TNBC
No prior PARP inhibitor exposure, no prior immunomodulatory drug exposure

Age Range

18 - 100

Healthy Volunteers Needed

No

Duration of Participation

You will receive the study drug for 13 cycles (approximately 52 weeks). If your cancer does not get worse and you do not have bad side effects the investigator may have you continue the study drug for longer than 13 cycles. After you finish study drug the investigator and/or study team will continue to watch you for side effects and follow your condition either with follow-up clinic visits or follow-up phone calls every 6 months for one year until the study has been completed.

Minors Included

No

Contact

Knight Cancer Institute Clinical Trials
trials@ohsu.edu
503 494-1080

Sponsor

OHSU Knight Cancer Institute

Recruitment End

11/30/2030

Compensation Provided

No


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